Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen
Identifieur interne : 004347 ( Main/Exploration ); précédent : 004346; suivant : 004348Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen
Auteurs : Carla J. Aldrich [États-Unis] ; Amy Decloux [États-Unis] ; Amina S. Woods [États-Unis] ; Robert J. Cotter [États-Unis] ; Mark J. Soloski [États-Unis] ; James Forman [États-Unis]Source :
- Cell [ 0092-8674 ] ; 1994.
English descriptors
- Teeft :
- Acad, Acid extraction, Acid extracts, Active fraction, Active fractions, Active peptide, Aldrich, Allele, Alloreactive, Alloreactive ctls, Alloreactive cytotoxic, Amaprtlll, Amino, Amino acid, Amino acids, Antigen, Antigen presentation, Bevan, Blmin gradient, Cell clones, Cell contact residue, Cell hybridomas, Cell lines, Cell receptor, Cell receptors, Cell recognition, Clone, Consensus peptide, Ctls, Cytotoxic, Determinant, Determinant modifier, Dmso, Dmso effect, Epitope, Fischer, Fischer lindahl, Forman, High determinant density, Histocompatibility, Hplc, Hplc fractions, Immune system, Immunol, Individual hplc fractions, Kind gift, Large array, Large number, Leader peptide, Leader sequence, Lindahl, Lymphoblast, Lymphocyte, Lysis, Major histocompatibility, Mass spectrometer, Mass spectrometry, Mass spectrum, Medical center, Molecular weight, Molecular weight peptides, Molecule, Mouse histocompatibility antigen, Mouse strains, Murine, Murine class, Mutant cell line, National institutes, Natl, Nonamer, Nonamer amaprtlll, Nonamer peptide, Open circles, Open diamonds, Open squares, Open triangles, Other class, Other peptides, Peptide, Peptide species, Polymorphism, Proc, Receptor, Room temperature, Same peptide, Sample site, Second gene, Sequence fragment, Shallow gradients, Signal recognition particle, Single peptide, Specialized role, Specific ctls, Stroynowski, Synthetic peptides, Target cell recognition, Target cells, Transporter, Wide array.
Abstract
Abstract: Recognition of the class Ib antigen Qa-1 by a portion of alloreactive cytotoxic T lymphocyte (CTL) clones requires that the target cell express a second gene, termed Qa-1 determinant modifier (Qdm). We show that Qdm is identical to most D allele genes, excepting Dk, and that a nonamer peptide derived from D alloantigens restores CTL recognition on cells that lack the Qdm-encoded determinant. The equivalent Dk peptide has an Ala→Val interchange at P3 and requires ∼4 logs more peptide than the AlaP3 peptide for target cell lysis. Two of five CTL clones, not dependent on Qdm for target cell recognition, also recognize the Qdm peptide as well as the ValP3 variant. Although the Qdm peptide spans residues 3–11 from the leader, it requires the Tap transporters for its expression. Thus, the response against this class Ib molecule provides a tool for dissecting alloreactivity as well as pathways for antigen presentation.
Url:
DOI: 10.1016/0092-8674(94)90550-9
Affiliations:
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Aldrich</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048</wicri:regionArea><wicri:noRegion>Texas 75235-9048</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>† Present address: Evansville Center, Indiana University School of Medicine, Evansville</wicri:cityArea></affiliation></author><author><name sortKey="Decloux, Amy" sort="Decloux, Amy" uniqKey="Decloux A" first="Amy" last="Decloux">Amy Decloux</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation></author><author><name sortKey="Woods, Amina S" sort="Woods, Amina S" uniqKey="Woods A" first="Amina S." last="Woods">Amina S. Woods</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation></author><author><name sortKey="Cotter, Robert J" sort="Cotter, Robert J" uniqKey="Cotter R" first="Robert J." last="Cotter">Robert J. Cotter</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Molecular Sciences Johns Hopkins University Medical School Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation></author><author><name sortKey="Soloski, Mark J" sort="Soloski, Mark J" uniqKey="Soloski M" first="Mark J." last="Soloski">Mark J. Soloski</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine Johns Hopkins University Medical School Baltimore, Maryland 21205</wicri:regionArea><wicri:noRegion>Maryland 21205</wicri:noRegion></affiliation></author><author><name sortKey="Forman, James" sort="Forman, James" uniqKey="Forman J" first="James" last="Forman">James Forman</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology University of Texas Southwestern Medical Center at Dallas Dallas, Texas 75235-9048</wicri:regionArea><wicri:noRegion>Texas 75235-9048</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell</title><title level="j" type="abbrev">CELL</title><idno type="ISSN">0092-8674</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">79</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="649">649</biblScope><biblScope unit="page" to="658">658</biblScope></imprint><idno type="ISSN">0092-8674</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0092-8674</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad</term><term>Acid extraction</term><term>Acid extracts</term><term>Active fraction</term><term>Active fractions</term><term>Active peptide</term><term>Aldrich</term><term>Allele</term><term>Alloreactive</term><term>Alloreactive ctls</term><term>Alloreactive cytotoxic</term><term>Amaprtlll</term><term>Amino</term><term>Amino acid</term><term>Amino acids</term><term>Antigen</term><term>Antigen presentation</term><term>Bevan</term><term>Blmin gradient</term><term>Cell clones</term><term>Cell contact residue</term><term>Cell hybridomas</term><term>Cell lines</term><term>Cell receptor</term><term>Cell receptors</term><term>Cell recognition</term><term>Clone</term><term>Consensus peptide</term><term>Ctls</term><term>Cytotoxic</term><term>Determinant</term><term>Determinant modifier</term><term>Dmso</term><term>Dmso effect</term><term>Epitope</term><term>Fischer</term><term>Fischer lindahl</term><term>Forman</term><term>High determinant density</term><term>Histocompatibility</term><term>Hplc</term><term>Hplc fractions</term><term>Immune system</term><term>Immunol</term><term>Individual hplc fractions</term><term>Kind gift</term><term>Large array</term><term>Large number</term><term>Leader peptide</term><term>Leader sequence</term><term>Lindahl</term><term>Lymphoblast</term><term>Lymphocyte</term><term>Lysis</term><term>Major histocompatibility</term><term>Mass spectrometer</term><term>Mass spectrometry</term><term>Mass spectrum</term><term>Medical center</term><term>Molecular weight</term><term>Molecular weight peptides</term><term>Molecule</term><term>Mouse histocompatibility antigen</term><term>Mouse strains</term><term>Murine</term><term>Murine class</term><term>Mutant cell line</term><term>National institutes</term><term>Natl</term><term>Nonamer</term><term>Nonamer amaprtlll</term><term>Nonamer peptide</term><term>Open circles</term><term>Open diamonds</term><term>Open squares</term><term>Open triangles</term><term>Other class</term><term>Other peptides</term><term>Peptide</term><term>Peptide species</term><term>Polymorphism</term><term>Proc</term><term>Receptor</term><term>Room temperature</term><term>Same peptide</term><term>Sample site</term><term>Second gene</term><term>Sequence fragment</term><term>Shallow gradients</term><term>Signal recognition particle</term><term>Single peptide</term><term>Specialized role</term><term>Specific ctls</term><term>Stroynowski</term><term>Synthetic peptides</term><term>Target cell recognition</term><term>Target cells</term><term>Transporter</term><term>Wide array</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Recognition of the class Ib antigen Qa-1 by a portion of alloreactive cytotoxic T lymphocyte (CTL) clones requires that the target cell express a second gene, termed Qa-1 determinant modifier (Qdm). We show that Qdm is identical to most D allele genes, excepting Dk, and that a nonamer peptide derived from D alloantigens restores CTL recognition on cells that lack the Qdm-encoded determinant. The equivalent Dk peptide has an Ala→Val interchange at P3 and requires ∼4 logs more peptide than the AlaP3 peptide for target cell lysis. Two of five CTL clones, not dependent on Qdm for target cell recognition, also recognize the Qdm peptide as well as the ValP3 variant. Although the Qdm peptide spans residues 3–11 from the leader, it requires the Tap transporters for its expression. Thus, the response against this class Ib molecule provides a tool for dissecting alloreactivity as well as pathways for antigen presentation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Aldrich, Carla J" sort="Aldrich, Carla J" uniqKey="Aldrich C" first="Carla J." last="Aldrich">Carla J. Aldrich</name></noRegion><name sortKey="Aldrich, Carla J" sort="Aldrich, Carla J" uniqKey="Aldrich C" first="Carla J." last="Aldrich">Carla J. Aldrich</name><name sortKey="Cotter, Robert J" sort="Cotter, Robert J" uniqKey="Cotter R" first="Robert J." last="Cotter">Robert J. Cotter</name><name sortKey="Decloux, Amy" sort="Decloux, Amy" uniqKey="Decloux A" first="Amy" last="Decloux">Amy Decloux</name><name sortKey="Forman, James" sort="Forman, James" uniqKey="Forman J" first="James" last="Forman">James Forman</name><name sortKey="Soloski, Mark J" sort="Soloski, Mark J" uniqKey="Soloski M" first="Mark J." last="Soloski">Mark J. Soloski</name><name sortKey="Woods, Amina S" sort="Woods, Amina S" uniqKey="Woods A" first="Amina S." last="Woods">Amina S. Woods</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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